Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion
作者： Thomas C. Hamilton , Margaret A. Winker , Karen G. Louie , Gerald Batist , Brent C. Behrens
DOI: 10.1016/0006-2952(85)90551-9
关键词: Cytotoxicity 、 Buthionine sulfoximine 、 Drug resistance 、 Biology 、 Chinese hamster ovary cell 、 Melphalan 、 Pharmacology 、 Cisplatin 、 Glutathione 、 Doxorubicin
摘要: Abstract The development of acquired resistance to antineoplastic drugs and the associated broad cross-resistance other agents frequently limits effectiveness chemotherapy. Ling coworkers have demonstrated that Chinese hamster ovary (CHO) cells develop phenotype pleiotropic drug which is manifest by a decrease in accumulation these hence cytotoxicity (1). role membrane glycoproteins expression primary human tumors an area active investigation (2–4). We developed series ovarian cancer cell lines with melphalan, cisplatin, or adriamycin (5). These exhibit sensitivity/resistance profiles characteristic resistance. In addition, melphalan cisplatin resistant variants are also cross-resistant irradiation (6). Both can be reversed lowering glutathione (GSH) levels buthionine sulfoximine (BSO) (6,7). present study, GSH sensitivity than was examined BSO-mediated depletion GSH. patterns both were compared following lines.
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sci-hub.se 参考文章(11)
Robert F. Ozols, Thomas C. Hamilton, Robert C. Young, Experimental model systems of ovarian cancer: applications to the design and evaluation of new treatment approaches Seminars in Oncology. ,vol. 11, pp. 285- 298 ,(1984) , 10.5555/URI:PII:0093775484901337
William H. Habig, William B. Jakoby, [27] Glutathione S-transferases (rat and human) Methods in Enzymology. ,vol. 77, pp. 218- 231 ,(1981) , 10.1016/S0076-6879(81)77029-0
Wilma M. McKoy, Karen R. Grotzinger, Timothy J. Kinsella, Karen G. Louie, Robert F. Ozols, Margaret A. Winker, Brent C. Behrens, Thomas C. Hamilton, Radiation Survival Parameters of Antineoplastic Drug-sensitive and -resistant Human Ovarian Cancer Cell Lines and Their Modification by Buthionine Sulfoximine Cancer Research. ,vol. 45, pp. 2110- 2115 ,(1985)
Shigeru Tsukagoshi, Harumi Iida, Yoshio Sakurai, Makiko Nojiri, Takashi Tsuruo, Circumvention of Vincristine and Adriamycin Resistance in Vitro and in Vivo by Calcium Influx Blockers Cancer Research. ,vol. 43, pp. 2905- 2910 ,(1983)
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Karen R. Grotzinger, Robert C. Young, James K. V. Willson, Robert F. Ozols, Cloning of Human Ovarian Cancer Cells in Soft Agar from Malignant Effusions and Peritoneal Washings Cancer Research. ,vol. 40, pp. 2743- 2747 ,(1980)
A. Rogan, T. Hamilton, R. Young, R. Klecker, R. Ozols, Reversal of adriamycin resistance by verapamil in human ovarian cancer Science. ,vol. 224, pp. 994- 996 ,(1984) , 10.1126/SCIENCE.6372095
Alessandra Eva, Keith C. Robbins, Philip R. Andersen, Alagarsamy Srinivasan, Steven R. Tronick, E. Premkumar Reddy, Nelson W. Ellmore, Angela T. Galen, James A. Lautenberger, Takis S. Papas, Eric H. Westin, Flossie Wong-Staal, Robert C. Gallo, Stuart A. Aaronson, Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells Nature. ,vol. 295, pp. 116- 119 ,(1982) , 10.1038/295116A0
Susan Somfai-Relle, Kayoko Suzukake, Barbara P. Vistica, David T. Vistica, Glutathione-conferred resistance to antineoplastics: approaches toward its reduction. Cancer Treatment Reviews. ,vol. 11, pp. 43- 54 ,(1984) , 10.1016/0305-7372(84)90042-2
Donald E. Paglia, William N. Valentine, Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase Journal of Laboratory and Clinical Medicine. ,vol. 70, pp. 158- 169 ,(1967) , 10.5555/URI:PII:0022214367900765