Polymorphisms in the ABC drug transporter gene MDR1.
作者： U Brinkmann , M Eichelbaum
关键词: Gene 、 Efflux 、 Genetic variability 、 Biology 、 Pharmacology 、 Pharmacogenetics 、 Drug 、 Bioavailability 、 P-glycoprotein 、 Knockout mouse 、 Genetics
摘要: In addition to genetically variable metabolic enzymes such as Cyp p450 proteins, blood and tissue levels of many drugs are influenced by controlled transport across compartmental boundaries. Major determinants in these processes ATP-dependent efflux pumps P-glycoprotein related proteins (eg MRPs), which can influence the bioavailability CNS concentrations, well disposition drugs. its recognized role development multiple chemotherapy resistances, experimental evidence for relevant MDR1 gene encoded P-glycoprotein, on pharmacology other has been gathered analyses knockout mice, clinical studies. Recently, functional genetic polymorphisms have identified distribution PGP substrates.
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