The choice of empirical antibiotic therapy for nosocomial pneumonia.

摘要: Nosocomial pneumonia has the highest crude mortality rate of all hospital-acquired infections. The choice empirical antibiotic therapy can be based on in vitro sensitivities sputum bacterial isolates. Organisms recovered from purulent 500 intensive care unit (ICU) patients five hospitals Louisville, Kentucky, had measured by microbroth dilution. most common isolates were Staphylococcus aureus (26.6%), Pseudomonas species (24.8%), Enterobacter (11.8%), Escherichia coli (7.2%), Klebsiella (7.0%), Streptococcus (4.4%) and Serratia (4.0%). These organisms tested for susceptibility to amikacin, ciprofloxacin, imipenem/cilastatin, ticarcillin/clavulanate, piperacillin, ceftriaxone ceftazidime. antibiotics effective against more than 80% seven included amikacin (97%), imipenem (94%), ciprofloxacin (92%) ticarcillin/clavulanate (84%). sensitivity patterns may serve as a guide choosing ICU-acquired Louisville. When use beta-lactam alone or combination with an aminoglycoside is preferred, ticarcillin-clavulanate considered choice. Studies are progress delineate clinical treating nosocomial pneumonia.