Dorzolamide versus pilocarpine as adjunctive therapies to timolol: a comparison of patient preference and impact on daily life

摘要: The purpose of this study was to compare 2% dorzolamide three times daily with pilocarpine four determine patient preference, tolerability, and impact on life in patients concurrently receiving 0.5% timolol twice for treatment elevated intraocular pressure (IOP). Seventy-five were enrolled 4-week, randomized, two-period, crossover study. Comparison Ophthalmic Medications Tolerability questionnaire used assess preference perception side effects activity limitations resulting from the medications. IOP measurements obtained 2 hours after drops instilled visual field tests performed at baseline end each period. Significantly more than reported adverse experiences discontinued drug because these experiences. Similarly, interference their when pilocarpine. Vision difficulties, accommodation brow ache often considered bothersome by Bitter/unusual taste frequently dorzolamide. Patients also missing fewer doses satisfied medication All changes statistically significant. control not significantly different either or However, experienced a significant worsening mean defect automated examinations At study, among preferred ratio 9:1. Overall, 81.9% Thus demonstrated better tolerability less