Chronic immune stimulation in adipose tissue and its consequences for health and performance in the pig.
作者： Kolapo M. Ajuwon
DOI: 10.1016/J.VETIMM.2014.02.013
关键词: Immune system 、 Adipokine 、 Adipose tissue 、 Biology 、 Inflammation 、 Endocrine system 、 Pattern recognition receptor 、 Downregulation and upregulation 、 Immunology 、 Innate immune system
摘要: The pig has been domesticated for about 13,000 years in multiple centers Europe, Eurasia and China. Chronic inflammation pigs is a major mitigating factor against optimal health growth performance. Therefore, strategies improving status of must involve downregulation inflammation. recent revelation that the adipose tissue an endocrine organ with immune function introduces exciting possibility also involved regulation response. expresses innate pattern recognition receptors through which able to recognize conserved pathogen structures, leading orchestration Experimental evidence indicates preadipocytes possess phagocytic properties may contribute clearance pathogens from circulation. A complication factor, however, activation response pathways adipocytes often associated onset chronic Because linked impairment animal efficiency, are needed minimize exposure factors activate pigs.
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