Efecto del aceite esencial de Aloysia triphylla britton (cedrón) sobre el Trypanosoma cruzi en ratones

摘要: Objectives. To determine the in-vivo anti-Trypanosoma cruzi activity of essential oil from Aloysiatriphylla in mice. Materials and methods. The mice (n = 15) study were randomly assigned to following groups: infected untreated (G1), treated with benznidazole 100 mg/kg (G2), (G3), 250 (G4), uninfected (G5), Aloysiatriphyla (G6). infection was conducted using 104 blood T. trypomastigotes treatment began on 8th day post-infection (dpi) through 28 dpi. parasitemia determined optical microscopy every 2 days 5 µL sampled tail. In dpi 14, 21 28, sample obtained queue for testing creatine kinase-MB, alanine aminotransferase creatinine, then animals euthanized heart removed histopathological study. Results. lemon verbena produced a significant reduction parasitemia, 85.4% peak at dose mg/ kg. It also observed number amastigotes inflammatory infiltrates heart. kinase-MB plasma levels decreased as result such treatment. Conclusions. Under experimental conditions, (lemon verbena) has vivo effect