Extent of mediastinal node metastasis in clinical stage I non-small-cell lung cancer: the role of systematic nodal dissection.

摘要: Abstract Objective : To determine the extent of lymph node metastasis in clinical stage I non-small-cell lung cancer (NSCLC). Methods We performed a retrospective review 524 patients with NSCLC who underwent lobectomy systematic nodal dissection. Results The status was N0 409 (78%), N1 44 (8%), N2 67 (13%), and N3 four (0.8%). Thirty-six had single-level mediastinal metastases 35 multi-level metastases. incidence N2/3 disease adenocarcinoma/squamous cell carcinoma/other histologic types according to tumor size 0/0/0%, respectively, tumors ≤10 mm diameter, 12/0/0% 11–20 14/4/23% 21–30 26/14/20% >30 diameter. Nodal upper mediastinum from middle or lower lobe lesions were frequently observed 51 adenocarcinomas, whereas those rare. Of 10 squamous carcinomas, seven regional three non-regional 5-year survival rate 68, 43, 30% N0, N1, N2, respectively ( P Conclusions Systematic dissection should be routinely for ensure correct status, but it might dispensable peripheral carcinoma ≤20 central ≤30 mm, adenocarcinoma mm. When cannot performed, taken account respect type, size, location tumor.