Opsonic activity of human immune serum on in vitro phagocytosis of Plasmodium falciparum infected red blood cells by monocytes.

摘要: In vitro human monocytes from normal blood donors ingest red cells infected with Plasmodium falciparum more efficiently than (NRBC). The phagocytic activity of for (IRBC) is greatly enhanced by the addition immune sera obtained individuals living in areas endemic malaria. contrast, recovering a first infection, or pooled sera, does not result increased phagocytosis IRBC. enhancing associated IgG fraction and depleted do stimulate phagocytosis. Enhanced serum mediated occurs as opsonization This was demonstrated experiments which IRBC were preincubated prior to assay. opsonic could be absorbed but NRBC. subsequent also dependent on stage development intracellular parasite. containing schizonts trophozoites preferentially phagocytosed compared ring forms. role malaria induced surface alterations and/or antigens discussed. These suggest that P. may play elimination infection humans.