Bacterial lipid membranes as promising targets to fight antimicrobial resistance, molecular foundations and illustration through the renewal of aminoglycoside antibiotics and emergence of amphiphilic aminoglycosides

摘要: Hereunder, we highlight bacterial membrane anionic lipids as attractive targets in the design of antibacterial drugs which can be effective against both Gram-positive and Gram-negative resistant bacteria. In this approach, first, molecular foundations structure–activity relationships are laid out for membrane-targeting drug candidates from structure physicochemical properties main targets, describing, well, corresponding identified resistances. Second, approach is illustrated by history emergence antifungal amphiphilic aminoglycosides (AAGs) active AAGs have resulted intensive medicinal chemistry development a group old antibiotic known (AGs), target ribosomal RNA. The aforementioned AAG's being used towards discovering new antibiotics less toxic susceptible to resistance. recent results field described discussed terms mechanism action.