Different effects of postnatal day 1 versus 7 192 immunoglobulin G-saporin lesions on learning, exploratory behaviors, and neurochemistry in juvenile rats.

摘要: Passive avoidance learning and retention, as well locomotor exploratory behaviors, were assessed in rats after intraventricular 192 immunoglobulin G-saporin injections on either Postnatal Day 1 (PND1) or PND7. PND1-lesioned not significantly impaired acquisition retention of passive avoidance. PND7-lesioned acquired the task slower than controls, but was affected. less controls showed reduced wall rearing. Histological analysis PND1- revealed no neuronal degeneration hippocampus cortex. There a marked reduction choline acetyltransferase (ChAT) activity hippocampus, cortex, septum slight significant ChAT depletion cortex rats. These data suggest that cholinergic system is critical for behaviors developing rat.