Mice lacking the gene encoding tissue-type plasminogen activator show a selective interference with late-phase long-term potentiation in both Schaffer collateral and mossy fiber pathways

摘要: The gene encoding tissue-type plasminogen activator (t-PA) is an immediate response gene, downstream from CREB-1 and other constitutively expressed transcription factors, which induced in the hippocampus during late phase of long-term potentiation (L-LTP). Mice t-PA has been ablated (t-PA-/-) showed no gross anatomical, electrophysiological, sensory, or motor abnormalities but manifest a selective reduction L-LTP hippocampal slices both Schaffer collateral-CA1 mossy fiber-CA3 pathways. t-PA-/- mice also exhibit reduced by cAMP analogs D1/D5 agonists. By contrast, hippocampal-dependent learning memory were not affected these mice, whereas performance was impaired on two-way active avoidance, striatum-dependent task. These results provide genetic evidence that effector important for show modest impairment CA1 CA3 does result hippocampus-dependent behavioral phenotypes.