Gene targeting: a novel window into the biology of learning and memory

摘要: Publisher Summary A number of techniques have been developed to manipulate the mouse genome. Genes can be added, deleted, or altered, and mice derived with mutations as subtle single nucleotide changes. This chapter highlights that studies done so far demonstrate possibility derive very restricted molecular, cellular, neuroanatomical, behavioral phenotypes. Decades on how what organisms learn remember given neuroscience a rich foundation, in which build theoretical experimental investigations learning memory. Beyond analysis, memory must also include information about neuroanatomy brain regions required for particular behaviors studied. A attest specificity deficits observed αCaMKII mutants. Surprisingly, spite this spatial deficit, performance mutants appears improve during training. The study homeotic has had widespread profound impact understanding development. All is expected from mutant tool specificity, flexibility, reliability, reproducibility.