Modeling Cognitive Disorders

作者: Alcino J. Silva , Rui M. Costa , Ype Elgersma

DOI: 10.1007/978-1-59259-353-8_3

关键词: Modern medicineCognitionSpatial learningHuman genomeComputer scienceProcess (engineering)Anticipation (genetics)Computational biologySequence (medicine)

摘要: The goal of the Human Genome Project was to map and sequence entire human genome. It with great anticipation that scientific community awaited completion genome project, as this information will revolutionize modern medicine in ways we are only starting realize. Of immediate consequence is enormous impact completed have on lengthy extremely laborious process mapping cloning disease loci. There no doubt availability shorten simplify process, next 10 years many genes underlying approx 12,000 genetic diseases known be mapped perhaps cloned.

参考文章(142)
Alcino J. Silva, Karl Peter Giese, Gene targeting: a novel window into the biology of learning and memory Neurobiology of Learning and Memory. pp. 89- 142 ,(1998) , 10.1016/B978-012475655-7/50004-6
Grace E. Holmes, Holly H. Ardinger, Donna K. Daily, Identification and Evaluation of Mental Retardation American Family Physician. ,vol. 61, pp. 1059- 1067 ,(2000)
Paul W. Frankland, Cara O'Brien, Masuo Ohno, Alfredo Kirkwood, Alcino J. Silva, α-CaMKII-dependent plasticity in the cortex is required for permanent memory Nature. ,vol. 411, pp. 309- 313 ,(2001) , 10.1038/35077089
Stephen M. Taubenfeld, Maria H. Milekic, Barbara Monti, Cristina M. Alberini, The consolidation of new but not reactivated memory requires hippocampal C/EBPβ Nature Neuroscience. ,vol. 4, pp. 813- 818 ,(2001) , 10.1038/90520
Karlyne M. Reilly, Dagan A. Loisel, Roderick T. Bronson, Margaret E. McLaughlin, Tyler Jacks, Nf1 ; Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects Nature Genetics. ,vol. 26, pp. 109- 113 ,(2000) , 10.1038/79075
Jonathan C. Gewirtz, Michael Davis, Second-order fear conditioning prevented by blocking NMDA receptors in amygdala Nature. ,vol. 388, pp. 471- 474 ,(1997) , 10.1038/41325
B.A. Oostra, E. Reyniers, C.E. Bakker, FMR1 Knockout mice: A model to study fragile X mental retardation American Journal of Human Genetics. ,vol. 55, ,(1994)
CA Barnes, MW Jung, BL McNaughton, DL Korol, K Andreasson, PF Worley, LTP saturation and spatial learning disruption: effects of task variables and saturation levels The Journal of Neuroscience. ,vol. 14, pp. 5793- 5806 ,(1994) , 10.1523/JNEUROSCI.14-10-05793.1994
S. M. Huson, D. F. Easton, M. A. Ponder, B. A. J. Ponder, An analysis of variation in expression of neurofibromatosis (NF) type 1 (NF1): evidence for modifying genes. American Journal of Human Genetics. ,vol. 53, pp. 305- 313 ,(1993)