Efficacy of dacarbazine (DTIC) in preventing metastases arising from intraocular melanomas in mice.

摘要: At present there are no chemotherapeutic agents that have been proven to be effective in either preventing or retarding the progression of metastases arising from uveal melanomas human subjects. Dacarbazine (DTIC), single most agent treatment cutaneous melanoma, is a potentially useful therapeutic modality for use as an antimetastatic melanoma. However, DTIC has not evaluated its ability impede originating intraocular melanomas. The study assessed efficacy murine melanoma model. results indicate with resulted sharp reductions number spontaneous and significant prolongation survival time. Dose-response studies indicated exceedingly high doses were necessary produce effects even when drug was combined calcium channel blocker verapamil. Collectively, can adjunctive administered at time enucleation melanoma-containing eye but ineffectual if subsequent surgery.