Ocular metastasis of in vivo and in vitro derived syngeneic murine melanoma.

摘要: We examine ocular metastasis of syngeneic murine melanoma in C57Bl/6J mice and compare the metastatic capability B16F10 tumor cells maintained vivo with those culture. demonstrate that as long are derived from an source, intraocular readily metastasizes to lungs. When is introduced intracameral (ic) cell suspension, or a solid fragment implanted on iris, 100% animals die extensive pulmonary 5-6 weeks later. In contrast, when passaged five times culture inoculated ic, marked decrease frequency extent metastasis, increase survival seen. These studies alteration ability cultured metastasize eye. eye was compared extraocular location, hosts same. The effect enucleation has only previously been examined using cells. this paper, we efficacy depends upon whether have vitro.