Quinolinic acid-induced lesions of the rat striatum: Quantitative autoradiographic binding assessment
作者： Marc Levivier , Serge Przedborski
DOI: 10.1080/01616412.1998.11740484
关键词: Striatum 、 Pharmacology 、 Adenosine A2A receptor 、 Neurochemical 、 PK-11195 、 CGS-21680 、 Receptor 、 Quinolinic acid 、 Dopamine 、 Chemistry
摘要: AbstractInjection of the excitatory amino-acid analog quinolinic acid into striatum rats produces neuropathological and neurochemical alterations that are reminiscent those observed in Huntington/s disease. In present study, we evaluated acid-induced striatal changes using quantitative autoradiographic binding assays for [3H]MK-801-labeled NMOA receptors, [3H]SCH 23390-labeled dopamine 0 7 [3 H]sulpiride-Iabeled O2 [3H]CGS 21680-labeled adenosine A2a [3H]mazindol-Iabeled uptake sites, [3H]hemicholinium-3-labeled high affinity choline sites [3H]PK 11195-labeled peripheral-type benzodiazepine as markers different cellular populations striatum. We found decrease [3H]MK 801 23390 binding, increase 11195 were most significant induced by intrastriatal injection acid. Concentrations 21680 [3H]hemicholinium-3 bindings we...
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