Influence of delta9-tetrahydrocannabinol and cannabidiol on photically evoked after-discharge potentials.

摘要: Two cannabinoids, Δ9 and cannabidiol, several reference drugs were compared relative to their effects in a recently developed anticonvulsant test system, the after-discharge potentials of visually evoked response; recorded electrophysiologically from electrodes permanently mounted over visual cortices conscious rats. In doses, trimethadione ethosuximide produced an extensive depression activity, whereas diphenylhydantoin cannabidiol exerted no such effect. contrast, doses subconvulsant pentylenetetrazol markedly increased which may represent manifestation central nervous system excitatory properties. The data present study support our previously published observations other tests that indicate characteristics resemble those rather than properties distinguish it cannabidiol. results consistently suggest cannabinoids will be effective against grand mal but not absence seizures.