Genetic background in nonalcoholic fatty liver disease: A comprehensive review

摘要: In the Western world, nonalcoholic fatty liver disease (NAFLD) is considered as one of most significant diseases twenty-first century. Its development certainly driven by environmental factors, but it also regulated genetic background. The role heritability has been widely demonstrated several epidemiological, familial, and twin studies case series, likely reflects wide inter-individual inter-ethnic variability in systemic metabolism wound healing response processes. Consistent with this idea, genome-wide association have clearly identified Patatin-like phosholipase domain-containing 3 gene variant I148M a major player progression NAFLD. More recently, transmembrane 6 superfamily member 2 E167K emerged relevant contributor both NAFLD pathogenesis cardiovascular outcomes. Furthermore, numerous case-control performed to elucidate potential candidate genes liver, although findings are sometimes contradictory. Accordingly, we comprehensive literature search review on genetics We emphasize strengths weaknesses available outline putative each influencing susceptibility and/or disease.