Neuroendocrine Disorders in Pediatric Craniopharyngioma Patients

摘要: Childhood-onset craniopharyngiomas are partly cystic embryonic malformations of the sellar/parasellar region. The therapy choice in patients with favorable tumor localization is complete resection a specific focus on maintaining optical and hypothalamic neuroendocrine functions. In unfavorable (i.e., involvement), limited hypothalamus-sparing surgical strategy followed by local irradiation recommended. Involvement and/or lesions posterior areas cause major sequelae. overall survival rates high (92%) but disorders such as obesity metabolic syndrome due to involvement treatment-related have negative impact quality life. Recurrences progressions frequent post-surgical events. Because efficient preventing progression, appropriate timing currently under investigation randomized multinational trial (KRANIOPHARYNGEOM 2007). craniopharyngioma should be recognized chronic disease requiring treatment constant monitoring clinical life consequences, frequently impaired disorders, experienced multidisciplinary teams order provide optimal care surviving patients.