Rate of accumulation of acetylcholine in discrete regions of the rat brain after dichlorvos treatment.
作者： W. B. Stavinoha , A. T. Modak , S. T. Weintraub
DOI: 10.1111/J.1471-4159.1976.TB02618.X
关键词: Cerebral cortex 、 Endocrinology 、 Acetylcholine 、 Cerebellum 、 Striatum 、 Chemistry 、 Hippocampus 、 Midbrain 、 Thalamus 、 Internal medicine 、 Dichlorvos 、 Anatomy
摘要: Abstract– The time course for accumulation of acetylcholine was measured in rat brain regions after treatment with 15 mg/kg, i.v., dichlorvos. With this dose dichlorvos 84-96% the cholinester-ase is inhibited within 1 min. After killing and concomitant enzyme inactivation through microwave irradiation, levels were by pyrolysis-gas chromatography. In studied, striatum had highest rate cerebellum lowest. calculated turnover minutes cerebral cortex 0.9; hippocampus 1; 1.4; 1.7; medulla-pons 2.2; midbrain 4.5; thalamus 5.6.
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