Evidence that adaptive cytoprotection in rats is not mediated by prostaglandins

摘要: Abstract We investigated the proposition that adaptive cytoprotection (enhanced gastric mucosal integrity) caused by exposure to 20% ethanol in rats is mediated endogenous prostaglandin synthesis. Experiments were performed both without and with indomethacin sufficient inhibit ex vivo release of E 2 56% ± 9% (2.5 mg/kg) or 86% 4% (10 mg/kg). Twenty percent significantly reduced macroscopic histologic signs injury subsequent 100% whether not pretreated indomethacin. itself extensive superficial disruption surface epithelium, so about half mucosa was covered desquamated debris, but did stimulate release. conclude still occurs after doses cause a profound depression The possibility it could be due formation protective covering debris worth further investigation.