Honokiol, a putative anxiolytic agent extracted from magnolia bark, has no diazepam-like side-effects in mice.

摘要: Use of the elevated plus-maze experiment and activity traction tests in mice have revealed that seven daily treatments with 0.2 mg kg(-1) higher doses honokiol, a neolignane derivative extracted from Magnolia bark, had an anxiolytic effect without change motor or muscle tone. Diazepam, 1 kg(-1), same potential as honokiol but induced relaxation. The aim this study was to determine whether diazepam-like side-effects. Mice treated 1-10 diazepam, not those 0.1-2 for 12 days showed withdrawal symptoms characterized by hyperactivity running-fit when they were challenge-administered intraperitoneal flumazenil (10 kg(-1)) 24 h after last treatment diazepam. Oral diazepam (0.5-2 10 min before) dose-dependently prolonged hexobarbital (100 i.p.)-induced sleeping, disrupted learning memory, inhibited (+)-bicuculline (40 death. Honokiol (0.2-20 p.o., 3 no such effects. prolongation (1 hexobarbital-induced sleeping modified kg(-1)). These results suggest is less likely than induce physical dependence, central depression amnesia at eliciting effect. It also considered might therapeutic convulsion.