Comparative assessment of the anxiolytic-like activities of honokiol and derivatives

摘要: Honokiol has previously been shown to be an effective anxiolytic-like agent in mice when administered for 7 days at 0.2 mg/kg/day prior evaluation elevated plus-maze, while 20 mg/kg is required efficacy as a single oral dose. The aim of this study was find analogs honokiol that are more acute administration. Among the eight evaluated, one partially reduced derivative [3'-(2-propenyl)-5-propyl-(1,1'-biphenyl)-2,4'-diol] exhibited significant activity 0.04 mg/kg. Following administration 1 analog, clearly evident h, peaked 3 and remained longer than 4 h after treatment. Combined with diazepam led enhanced efficacy. Moreover, diazepam, effect analog by flumazenil. In contrast, bicuculline, GABA(A) antagonist, had no on derivative. Taken together, these results suggest acts benzodiazepine recognition site GABA(A)-benzodiazepine receptor complex.