Neurotrophic activity of honokiol on the cultures of fetal rat cortical neurons
作者： Yoshiyasu Fukuyama , Kousuke Nakade , Yuka Minoshima , Ritsuko Yokoyama , Haifeng Zhai
DOI: 10.1016/S0960-894X(02)00112-9
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摘要: Abstract Honokiol, a main biphenyl neolignan of the traditional crude medicine, Magnoliae cortex, was found to show neurotrophic activity on cultures rat cortical neurons at concentration from 0.1 10 μM. In cultured in serum-free medium supplemented with B27, honokiol could promote neurite outgrowth. addition, survival and growth were significantly enhanced by adding primary N2. Its comparable 40 ng mL−1 bFGF
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