Emergent Stratification in Solid Tumors Selects for Reduced Cohesion of Tumor Cells: A Multi-Cell, Virtual-Tissue Model of Tumor Evolution Using CompuCell3D.
作者： Maciej H. Swat , Gilberto L. Thomas , Abbas Shirinifard , Sherry G. Clendenon , James A. Glazier
DOI: 10.1371/JOURNAL.PONE.0127972
关键词: Cell aging 、 Cell adhesion molecule 、 Cell adhesion 、 Cell 、 Integrin 、 Bioinformatics 、 Somatic evolution in cancer 、 Cadherin 、 Biology 、 Neuroscience 、 Mitosis
摘要: Tumor cells and structure both evolve due to heritable variation of cell behaviors selection over periods weeks years (somatic evolution). Micro-environmental factors exert pressures on tumor-cell behaviors, which influence the rate direction evolution specific especially development aggression resistance chemotherapies. In this paper, we present, step-by-step, a multi-cell, virtual-tissue model tumor somatic evolution, simulated using open-source CompuCell3D modeling environment. Our includes essential microenvironmental components their interactions. provides platform for exploring leading aggression, showing that emergent stratification into regions with different survival rates drives less cohesive lower levels cadherins higher integrins. Such reduced cohesivity is key hallmark in progression many types solid tumors.
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