Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein

作者: Pingyan Cheng , Cesar A. Corzo , Noreen Luetteke , Bin Yu , Srinivas Nagaraj

DOI: 10.1084/JEM.20080132

关键词: S100A9Embryonic stem cellCell biologyDendritic cellDendritic cell differentiationTransgeneCellular differentiationImmune systemMyeloid-derived Suppressor CellBiology

摘要: … in cancer inhibits DC and macrophage differentiation and … To determine whether MDSC accumulation requires S100A9… We asked whether ROS affected the differentiation of MDSCs …

参考文章(59)
C. Menetrier-Caux, G. Montmain, M.C. Dieu, C. Bain, M.C. Favrot, C. Caux, J.Y. Blay, Inhibition of the Differentiation of Dendritic Cells From CD34+ Progenitors by Tumor Cells: Role of Interleukin-6 and Macrophage Colony-Stimulating Factor Blood. ,vol. 92, pp. 4778- 4791 ,(1998) , 10.1182/BLOOD.V92.12.4778
Pingyan Cheng, Andrew Zlobin, Veronica Volgina, Sridevi Gottipati, Barbara Osborne, Erica J. Simel, Lucio Miele, Dmitry I. Gabrilovich, Notch-1 Regulates NF-κB Activity in Hemopoietic Progenitor Cells Journal of Immunology. ,vol. 167, pp. 4458- 4467 ,(2001) , 10.4049/JIMMUNOL.167.8.4458
Kim H. T. Paraiso, Tomar Ghansah, Amy Costello, Robert W. Engelman, William G. Kerr, Induced SHIP Deficiency Expands Myeloid Regulatory Cells and Abrogates Graft-versus-Host Disease Journal of Immunology. ,vol. 178, pp. 2893- 2900 ,(2007) , 10.4049/JIMMUNOL.178.5.2893
Sergei Kusmartsev, Yulia Nefedova, Daniel Yoder, Dmitry I. Gabrilovich, Antigen-specific inhibition of CD8+ T cell response by immature myeloid cells in cancer is mediated by reactive oxygen species. Journal of Immunology. ,vol. 172, pp. 989- 999 ,(2004) , 10.4049/JIMMUNOL.172.2.989
Shin-ichi Hashimoto, Takuji Suzuki, Hong-Yan Dong, Shigenori Nagai, Nobuyuki Yamazaki, Kouji Matsushima, Serial analysis of gene expression in human monocyte-derived dendritic cells. Blood. ,vol. 94, pp. 845- 852 ,(1999) , 10.1182/BLOOD.V94.3.845.415K09_845_852
Bond Almand, Joseph I. Clark, Ekaterina Nikitina, James van Beynen, Nicholas R. English, Stella C. Knight, David P. Carbone, Dmitry I. Gabrilovich, Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer. Journal of Immunology. ,vol. 166, pp. 678- 689 ,(2001) , 10.4049/JIMMUNOL.166.1.678
Jacques Doussiere, Farid Bouzidi, Pierre V. Vignais, The S100A8/A9 protein as a partner for the cytosolic factors of NADPH oxidase activation in neutrophils. FEBS Journal. ,vol. 269, pp. 3246- 3255 ,(2002) , 10.1046/J.1432-1033.2002.03002.X
Sergei Kusmartsev, Srinivas Nagaraj, Dmitry I. Gabrilovich, Tumor-Associated CD8+ T Cell Tolerance Induced by Bone Marrow-Derived Immature Myeloid Cells Journal of Immunology. ,vol. 175, pp. 4583- 4592 ,(2005) , 10.4049/JIMMUNOL.175.7.4583
Keith L. Knutson, Hailing Lu, Brad Stone, Jennifer M. Reiman, Marshall D. Behrens, Christine M. Prosperi, Ekram A. Gad, Arianna Smorlesi, Mary L. Disis, Immunoediting of cancers may lead to epithelial to mesenchymal transition Journal of Immunology. ,vol. 177, pp. 1526- 1533 ,(2006) , 10.4049/JIMMUNOL.177.3.1526
Kelli P. A. MacDonald, Vanessa Rowe, Andrew D. Clouston, Joseph K. Welply, Rachel D. Kuns, James L. M. Ferrara, Ranjeny Thomas, Geoffrey R. Hill, Cytokine expanded myeloid precursors function as regulatory antigen-presenting cells and promote tolerance through IL-10-producing regulatory T cells. Journal of Immunology. ,vol. 174, pp. 1841- 1850 ,(2005) , 10.4049/JIMMUNOL.174.4.1841