MicroRNAs and Discovery of New Targets
作者： Soken Tsuchiya , Yasushi Okuno , Gozoh Tsujimoto
DOI: 10.1007/978-1-60327-088-5_4
关键词: Untranslated region 、 Cancer 、 microRNA 、 Non-coding RNA 、 Biology 、 Cancer research 、 Oncogene 、 Gene expression 、 Tumor suppressor gene 、 Drug discovery
摘要: MicroRNAs are endogenous short non-coding RNAs that regulate gene expression mainly at the post-transcriptional level by base pairing to 3′ untranslated region of target messenger RNAs. At present, hundreds microRNAs have been identified in humans, and some them revealed play a critical role especially initiation, progression, malignant potential various cancers. In this chapter, we discuss cancer its application for therapy.
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sci-hub.st 参考文章(74)
David P Bartel, MicroRNAs: Genomics, Biogenesis, Mechanism, and Function Cell. ,vol. 116, pp. 281- 297 ,(2004) , 10.1016/S0092-8674(04)00045-5
William C. Hahn, Christopher M. Counter, Ante S. Lundberg, Roderick L. Beijersbergen, Mary W. Brooks, Robert A. Weinberg, Creation of human tumour cells with defined genetic elements Nature. ,vol. 400, pp. 464- 468 ,(1999) , 10.1038/22780
Aurora Esquela-Kerscher, Frank J. Slack, Oncomirs — microRNAs with a role in cancer Nature Reviews Cancer. ,vol. 6, pp. 259- 269 ,(2006) , 10.1038/NRC1840
Amy E Pasquinelli, Brenda J Reinhart, Frank Slack, Mark Q Martindale, Mitzi I Kuroda, Betsy Maller, David C Hayward, Eldon E Ball, Bernard Degnan, Peter Müller, Jürg Spring, Ashok Srinivasan, Mark Fishman, John Finnerty, Joseph Corbo, Michael Levine, Patrick Leahy, Eric Davidson, Gary Ruvkun, None, Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA Nature. ,vol. 408, pp. 86- 89 ,(2000) , 10.1038/35040556
Mariana Lagos-Quintana, Reinhard Rauhut, Abdullah Yalcin, Jutta Meyer, Winfried Lendeckel, Thomas Tuschl, Identification of tissue-specific microRNAs from mouse Current Biology. ,vol. 12, pp. 735- 739 ,(2002) , 10.1016/S0960-9822(02)00809-6
P. S. Eis, W. Tam, L. Sun, A. Chadburn, Z. Li, M. F. Gomez, E. Lund, J. E. Dahlberg, Accumulation of miR-155 and BIC RNA in human B cell lymphomas Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 3627- 3632 ,(2005) , 10.1073/PNAS.0500613102
L. Zhang, J. Huang, N. Yang, J. Greshock, M. S. Megraw, A. Giannakakis, S. Liang, T. L. Naylor, A. Barchetti, M. R. Ward, G. Yao, A. Medina, A. O'Brien-Jenkins, D. Katsaros, A. Hatzigeorgiou, P. A. Gimotty, B. L. Weber, G. Coukos, microRNAs exhibit high frequency genomic alterations in human cancer Proceedings of the National Academy of Sciences of the United States of America. ,vol. 103, pp. 9136- 9141 ,(2006) , 10.1073/PNAS.0508889103
Lee P Lim, Margaret E Glasner, Soraya Yekta, Christopher B Burge, David P Bartel, Vertebrate microRNA genes. Science. ,vol. 299, pp. 1540- 1540 ,(2003) , 10.1126/SCIENCE.1080372
Jia Yu, Fang Wang, Gui-Hua Yang, Fan-Long Wang, Yan-Ni Ma, Zhan-Wen Du, Jun-Wu Zhang, Human microRNA clusters: genomic organization and expression profile in leukemia cell lines. Biochemical and Biophysical Research Communications. ,vol. 349, pp. 59- 68 ,(2006) , 10.1016/J.BBRC.2006.07.207
Kent Hunter, Host genetics influence tumour metastasis Nature Reviews Cancer. ,vol. 6, pp. 141- 146 ,(2006) , 10.1038/NRC1803