A sufentanil dosage study in general surgery

摘要: Sufentanil is widely used for cardiac surgery in initial doses up to 15 micrograms/kg. It was expected that general much smaller would be appropriate. The aim of the study, therefore, find a dosage scheme sufentanil could operations lasting 1 h. METHODS. In 62 patients (Table 1), anesthesia induced with micrograms and 0.2 mg/kg etomidate. According random group allocation, bolus injection administered min before incision, so received 0.5, 1.0 or 1.5 micrograms/kg along dose. During maintenance anesthesia, repeat 10 were injected as required (rise blood pressure and/or heart rate by more than 20%, other stress signs i.e., sweating, movement). Intubation facilitated means atracurium 0.5 mg/kg. Increments 5-10 mg given when needed. RESULTS. who had micrograms/kg, both number requiring doses, total significantly lower microgram/kg group. A further increase did not prove have any advantage it led drop pressure, pronounced longer duration groups. CONCLUSION. dose appeared optimum at least