術後肝転移を来し切除しえた膵solid-pseudopapillary tumorの1例
作者： Hidenobu Okino , Motomasa Hiroyoshi , Yoshiki Kitaura , Koji Onitsuka , Masaki Shono
DOI: 10.5833/JJGS.39.340
关键词: Solid pseudopapillary tumor 、 Radiology 、 Chemistry
摘要: 歳の女性で, 膵Solid-pseudopapillary tumor (以下, PSPT) の診断で膵体尾部脾合併切除術を施行後, 2年5か月後に多発肝転移を認め肝前区域切除術, ラジオ波焼灼術を施行した. PSPTは若い女性に好発する予後良好な腫瘍と認識されているが, 肝転移を伴う症例での死亡報告例が集積し必ずしも予後良好な腫瘍とは言いがたい. 本邦における肝転移症例50例を通常のPSPTと比較すると, 平均年齢は約15歳高齢で, 原発巣は膵頭部に少なく, 約15mm腫瘍径が大きかった. 肝転移まで平均6.8年を要し, 転移は多発する傾向にあり, 手術施行群が未施行群に対し生存率が高く, 化学療法は無効であった. したがって, 術後長期のフォローアップが必要で肝転移を認めた場合は積極的に手術を行うべきである. 通常の膵管癌とPSPTは発癌の機序が異なり, これが性差や予後の違いを反映することが近年分子生物学的に徐々に解明されつつある.
sci-hub.se 参考文章(16)
Masateru Taniguchi, Akira Sano, Manabu Uchida, Kuniaki Hirabayashi, Koji Hazano, Yukio Masuki, Systemic lupus erythematosusに併存した肝転移を伴う膵solid cystic tumorの1例 The Japanese Journal of Gastroenterological Surgery. ,vol. 31, pp. 2094- 2098 ,(1998) , 10.5833/JJGS.31.2094
K. Nishihara, M. Tsuneyoshi, A. Ohshima, K. Yamaguchi, Papillary Cystic Tumor of the Pancreas: Is it a Hormone-dependent Neoplasm? Pathology Research and Practice. ,vol. 189, pp. 521- 526 ,(1993) , 10.1016/S0344-0338(11)80359-6
M Kasahara, T Funabiki, T Sakamoto, M Ochiai, H Amano, K Kamei, Three cases of solid and cystic tumor of the pancreas. Analysis comparing the histopathological findings and DNA histograms. International Journal of Pancreatology. ,vol. 10, pp. 269- 278 ,(1991) , 10.1007/BF02924165
Yukihiko Matsuda, Yasuharu Imai, Sumio Kawata, Masahiro Nishikawa, Shio Miyoshi, Ryuzo Saito, Yuzo Minami, Seiichiro Tarui, Papillary-cystic neoplasm of the pancreas with multiple hepatic metastases: A case report Gastroenterologia Japonica. ,vol. 22, pp. 379- 384 ,(1987) , 10.1007/BF02774265
Robert C. G. Martin, David S. Klimstra, Murray F. Brennan, Kevin C. Conlon, Solid-pseudopapillary tumor of the pancreas : a surgical enigma? Annals of Surgical Oncology. ,vol. 9, pp. 35- 40 ,(2002) , 10.1245/ASO.2002.9.1.35
J Müller-Höcker, Ch Zietz, A Sendelhofert, Deregulated expression of cell cycle-associated proteins in solid pseudopapillary tumor of the pancreas. Modern Pathology. ,vol. 14, pp. 47- 53 ,(2001) , 10.1038/MODPATHOL.3880255
Mary B. Wilson, David B. Adams, Paul D. Garen, Ted S. Gansler, Aspiration cytologic, ultrastructural, and DNA cytometric findings of solid and papillary tumor of the pancreas. Cancer. ,vol. 69, pp. 2235- 2243 ,(1992) , 10.1002/1097-0142(19920501)69:9<2235::AID-CNCR2820690905>3.0.CO;2-P
Minoru Horisawa, Noriji Nijnomi, Taichiro Sato, Syunpei Yokoi, Koji Oda, Masaaki Ichikawa, Seijun Hayakawa, Frantz's tumor (solid and cystic tumor of the pancreas) with liver metastasis: Successful treatment and long-term follow-up Journal of Pediatric Surgery. ,vol. 30, pp. 724- 726 ,(1995) , 10.1016/0022-3468(95)90701-7
Laura H Tang, Hakan Aydin, Murray F Brennan, David S Klimstra, Clinically Aggressive Solid Pseudopapillary Tumors of the Pancreas: A Report of Two Cases With Components of Undifferentiated Carcinoma and a Comparative Clinicopathologic Analysis of 34 Conventional Cases The American Journal of Surgical Pathology. ,vol. 29, pp. 512- 519 ,(2005) , 10.1097/01.PAS.0000155159.28530.88
Kazuyoshi Nishihara, Makoto Nagoshi, Masazumi Tsuneyoshi, Koji Yamaguchi, Itsuro Hayashi, Papillary cystic tumors of the pancreas. Assessment of their malignant potential. Cancer. ,vol. 71, pp. 82- 92 ,(1993) , 10.1002/1097-0142(19930101)71:1<82::AID-CNCR2820710114>3.0.CO;2-Y