The interleukin-8-251*T/*A polymorphism is not associated with risk for gastric carcinoma development in a Portuguese population.
作者： Paulo Canedo , Abel J. Castanheira-Vale , Nuno Lunet , Fábio Pereira , Céu Figueiredo
DOI: 10.1097/CEJ.0B013E32809B4D0F
关键词: Portuguese population 、 Gastric carcinoma 、 Interleukin 8 、 Chronic gastritis 、 Helicobacter 、 Internal medicine 、 Population 、 Interleukin 、 Gastroenterology 、 Stomach 、 Biology
摘要: It has been demonstrated that polymorphisms within inflammation-related genes are associated with risk of gastric carcinoma in Helicobacter pylori-infected individuals. Recently, several studies have reported conflicting results regarding the association between interleukin (IL)8-251*T/*A polymorphism and carcinoma. In this study, we performed a case-control analysis, including 693 controls, 187 chronic gastritis cases 333 cases, to determine IL8-251 northern Portugal population. We found no significant increased or carcinoma, agreement other populations white origin. The retrospective analysis published data shows tends be reproducible Asian estimated effect under was not significantly different subgroups defined by histologic type anatomic site tumours, sex age participants. conclusion our indicate although might relevant host susceptibility factor for development, is likely ethnic-specific.
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