Current knowledge about the functional roles of phosphorylative changes of membrane proteins in normal and diseased red cells.

摘要: With the advent of proteomic techniques number known post-translational modifications (PTMs) affecting red cell membrane proteins is rapidly growing but understanding their role under physiological and pathological conditions incompletely established. The wide range hereditary diseases different functions induced by malaria parasite intracellular growth represent a unique opportunity to study PTMs in response variable cellular stresses. In present review, some major areas interest research have been considered as erythrocyte deformability maintenance surface area, transport alterations, removal diseased senescent cells. all mentioned functional roles are prevalently restricted phosphorylative changes more abundant proteins. insufficient information about occurring large majority general lack mass spectrometry data evidence need new comprehensive, approaches improve physiology.