Differential enhancement of rapid eye movement sleep signs in the cat: a comparison of microinjection of the cholinergic agonist carbachol and the β-adrenergic antagonist propranolol on pontogeniculo-occipital wave clusters

摘要: Abstract The cholinergic agonist carbachol and the β-adrenergic antagonist propranolol were microinjected at same pontine sites their effects on polygraphic rapid eye movement (REM) sleep, especially pontogeniculo-occipital (PGO) waves, measured. While both enhanced PGO wave activity REM carbachol-correlated enhancement was more impressive. increases in sleep signs elicited by 5-fold over baseline lasted throughout 4-h recording period. Propranolol 2.5-fold that significant first 2 h only. Yet, increase evoked equal to of during non-REM wakefulness. results indicate while is less potent activating distributed neuronal network responsible for generation, it selectively facilitates part waves.