Microinjection of neostigmine into the pontine reticular formation of the mouse: further evaluation of a proposed REM sleep enhancement technique
作者： Michael S. Pollock , Ralph E. Mistlberger
DOI: 10.1016/J.BRAINRES.2004.10.056
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摘要: Microinjections of cholinergic agonists into the pontine reticular formation (PRF) powerfully induce rapid eye movement sleep (REMS) in cats but have comparatively weaker effects rats. Recently, cholinomimetic neostigmine has been reported to strongly enhance REMS following microinjection PRF mouse. That study used behavioral assessments locomotion lieu electrophysiological measures muscle tone identify REMS. We sought confirm that state induced mice by injections meets standard electroencephalogram (EEG) and electromyogram (EMG) criteria for defining Cortical EEG, nuchal EMG, PGO waves were recorded from male C57BL/6N with chronic indwelling cannulae delivery PRF. Recordings made during midday (8.8 mM, 50 nl), 2 h after lights on (LD 12:12). Neostigmine a characterized low amplitude, highly desynchronized cortical EEG little theta, no waves, sustained high tone. Behavioral states meeting slow-wave (SWS) significantly suppressed compared baseline recordings, onset was delayed 3 h. Consistent earlier reports, did suppress locomotor activity open field tests home cage. Due failure meet REMS, we conclude mouse induces an abnormal waking rather than
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