Using Xenopus to understand human disease and developmental disorders.
作者： Amy K. Sater , Sally A. Moody
DOI: 10.1002/DVG.22997
关键词: Biomedicine 、 Genome editing 、 Proteomics 、 Xenopus 、 Computational biology 、 Functional genomics 、 Biology 、 Developmental biology 、 Genetics 、 Genomics 、 Cost effectiveness
摘要: Model animals are crucial to biomedical research. Among the commonly used model animals, amphibian, Xenopus, has had tremendous impact because of its unique experimental advantages, cost effectiveness, and close evolutionary relationship with mammals as a tetrapod. Over past 50 years, use Xenopus made possible many fundamental contributions biomedicine, it is cornerstone research in cell biology, developmental immunology, molecular neurobiology, physiology. The prospects for an system excellent: uniquely well-suited contemporary approaches study biological disease mechanisms. Moreover, recent advances high throughput DNA sequencing, genome editing, proteomics, pharmacological screening easily applicable enabling rapid functional genomics human modeling at systems level.
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