Bone mineral density in children with sickle cell anemia.
作者： Ashutosh Lal , Ellen B. Fung , Zahra Pakbaz , Ekua Hackney-Stephens , Elliott P. Vichinsky
DOI: 10.1002/PBC.20681
关键词: Internal medicine 、 Gastroenterology 、 Vitamin D and neurology 、 Bone density 、 Endocrinology 、 Population study 、 Hemoglobinopathy 、 Hemolytic anemia 、 Bone mineral 、 Sickle cell anemia 、 Anemia 、 Medicine
摘要: Purpose We evaluated bone mineral density (BMD) and risk factors for poor mineralization in children with sickle cell anemia (SCA). Patients Methods Twenty-five severe manifestations of SCA (frequent hospitalizations, growth delay, or need chronic red transfusions) were enrolled. Bone was assessed at lumbar spine proximal femur dual-energy X-ray absorptiometry (DXA), Z-scores calculated by comparison age, sex, ethnicity-specific reference data. Results The median age the study population 12.8 years (10.2–19.8 years). Calcium intake inadequate 60%, serum 25-hydroxy vitamin D (25-OHD) level <50 nM 74% patients. Median (−2.3) (−1.7) markedly reduced, 64% (95% confidence interval, 43%–82%) patients had low density. not related to transfusions, ferritin level. Conclusion Our results suggest that have BMD, possess significant deficits dietary calcium circulating D. Pediatr Blood Cancer © 2005 Wiley-Liss, Inc.
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