Definition of two regions of deletion on chromosome 9 in carcinoma of the bladder

摘要: Loss of heterozygosity (LOH) at loci on chromosome 9 can be detected in more than 50% bladder tumours, suggesting the presence this one or suppressor genes for carcinogenesis. Localisation target gene(s) by deletion mapping has previously proved difficult due to uneven distribution polymorphic and finding LOH all these majority tumours. We have used a panel 22 highly informative microsatellite markers, evenly distributed along analyse 95 cases primary transitional cell carcinoma bladder. Forty nine tumours (53%) showed loci. Of these, 30 had loci, indicating probable monosomy 9. Nineteen (22%) subchromosomal deletions, 5 9p only, 9q only both with clear region retention between. The patterns indicated common between D9S126 (9p21) IFNA (9p21). A single tumour second site telomeric possible existence 2 9p. All deletions were large, D9S15 (9q13-q21.1) D9S60 (9q33-q34.1). These results indicate much higher frequency been provide evidence simultaneous involvement distinct carcinoma.