R2* magnetic resonance imaging of the liver in patients with iron overload
作者： Jane S. Hankins , M. Beth McCarville , Ralf B. Loeffler , Matthew P. Smeltzer , Mihaela Onciu
DOI: 10.1182/BLOOD-2008-12-191643
关键词: Liver Iron Concentration 、 Biopsy 、 Bone marrow failure 、 Nuclear medicine 、 Intraclass correlation 、 Sickle cell anemia 、 Liver biopsy 、 Magnetic resonance imaging 、 Medicine 、 Pathology 、 Ferritin
摘要: R2* magnetic resonance imaging (R2*-MRI) can quantify hepatic iron content (HIC) by noninvasive means but is not fully investigated. Patients with overload completed 1.5T R2*-MRI examination and liver biopsy within 30 days. Forty-three patients (sickle cell anemia, n = 32; beta-thalassemia major, 6; bone marrow failure, 5) were analyzed: median age, 14 years, transfusion duration, 15 months, average (+/-SD) serum ferritin 2718 plus or minus 1994 ng/mL, HIC 10.9 6.8 mg Fe/g dry weight liver. Regions of interest drawn analyzed 3 independent reviewers excellent agreement their measurements (intraclass correlation coefficient 0.98). Ferritin weakly significantly associated (range coefficients among the reviewers, 0.41-0.48; all P < .01). was strongly for (correlation coefficients, 0.96-0.98; .001). This high confirms prior reports, calibrates measurements, suggests its clinical utility predicting using R2*-MRI. study registered at www.clinicaltrials.gov as #NCT00675038.
ashpublications.org
bloodjournal.org
elsevier.com参考文章(16)
Yves M. Deugnier, Olivier Loréal, Bruno Turlin, Dominique Guyader, Hervé Jouanolle, Romain Moirand, Christian Jacquelinet, Pierre Brissot, Liver pathology in genetic hemochromatosis: A review of 135 homozygous cases and their bioclinical correlations Gastroenterology. ,vol. 102, pp. 2050- 2059 ,(1992) , 10.1016/0016-5085(92)90331-R
K Linnet, I Bruunshuus, HPLC with enzymatic detection as a candidate reference method for serum creatinine. Clinical Chemistry. ,vol. 37, pp. 1669- 1675 ,(1991) , 10.1093/CLINCHEM/37.10.1669
John C. Wood, Cathleen Enriquez, Nilesh Ghugre, J. Michael Tyzka, Susan Carson, Marvin D. Nelson, Thomas D. Coates, MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients Blood. ,vol. 106, pp. 1460- 1465 ,(2005) , 10.1182/BLOOD-2004-10-3982
José M. Alústiza, José Artetxe, Agustín Castiella, Cristina Agirre, José I. Emparanza, Pedro Otazua, Manuel García-Bengoechea, Jesús Barrio, Fernando Mújica, José A. Recondo, MR Quantification of Hepatic Iron Concentration Radiology. ,vol. 230, pp. 479- 484 ,(2004) , 10.1148/RADIOL.2302020820
Matthew D. Robson, Peter D. Gatehouse, Mark Bydder, Graeme M. Bydder, Magnetic resonance: an introduction to ultrashort TE (UTE) imaging. Journal of Computer Assisted Tomography. ,vol. 27, pp. 825- 846 ,(2003) , 10.1097/00004728-200311000-00001
Kamal Ishak, Amelia Baptista, Leonardo Bianchi, Francesco Callea, Jan De Groote, Fred Gudat, Helmut Denk, Valeer Desmet, Gerhard Korb, Roderick N.M. MacSween, M.James Phillips, Bernard G. Portmann, Hemming Poulsen, Peter J. Scheuer, Martin Schmid, Heribert Thaler, Histological grading and staging of chronic hepatitis. Journal of Hepatology. ,vol. 22, pp. 696- 699 ,(1995) , 10.1016/0168-8278(95)80226-6
Neal S. Young, Christopher J. Allen, David E. Farrell, John W. Harris, Gary M. Brittenham, Alan R. Cohen, Christine E. McLaren, Marie B. Martin, Patricia M. Griffith, Arthur W. Nienhuis, Hepatic iron stores and plasma ferritin concentration in patients with sickle cell anemia and thalassemia major American Journal of Hematology. ,vol. 42, pp. 81- 85 ,(1993) , 10.1002/AJH.2830420116
J. Martin Bland, Douglas G. Altman, Statistical methods for assessing agreement between two methods of clinical measurement International Journal of Nursing Studies. ,vol. 47, pp. 931- 936 ,(2010) , 10.1016/J.IJNURSTU.2009.10.001
Victor J. Yohai, HIGH BREAKDOWN-POINT AND HIGH EFFICIENCY ROBUST ESTIMATES FOR REGRESSION Annals of Statistics. ,vol. 15, pp. 642- 656 ,(1987) , 10.1214/AOS/1176350366
J. Martin Bland, DouglasG. Altman, Statistical methods for assessing agreement between two methods of clinical measurement. The Lancet. ,vol. 327, pp. 307- 310 ,(1986) , 10.1016/S0140-6736(86)90837-8