New variants of human papillomavirus type 18 identified in central Brazil.

摘要: HPV-18 is the second most prevalent human papillomavirus genotype found in cervical cancer. Nucleotide variations sequence can interfere with viral oncogenic potential. However, knowledge about variants Brazil still limited. The present study aims to determine LCR, E6, and L1 genetic variability of women co-infected HIV-1 Central Brazil. Four samples were identified had genomic regions sequenced. It was possible characterize three European one African variant HPV-18. All them are new variants, showing nucleotide substitutions not previously reported. binding sites for transcriptional factors observed. Phylogenetic analysis also performed, evidencing clusters related Asian-American, African, variants. characterization HPV pivotal importance understanding pathogenicity.