Gut motility and visceral perception in IBS patients

摘要: SUMMARY Although IBS is the most common functional disorder of alimentary tract in western countries, its pathogenesis is still not fully understood. It seems that multiple precipitating factors alter gut motility and visceral perception, resulting in specific motor function disorders. These disorders seem to differ between patients presenting with constipation and those diarrhea. The common motility disorders found include the frequency of high amplitude propagating contractions (HAPC), contractile activity rectosigmoid, the motor changes after ingestion food. presence of a generalized alimentary in IBS, suggests presence systematic neuromuscular dysfunction. In two-thirds patients, disturbance visceral perception hypersensitivity as response to either normal, or abnormal stimuli, exists. Despites the fact actual mechanisms responsible for these disorders are, yet, partially unknown, there body evidence that brain-gut axis dysfunction, further impaired by psychological stress, may be leading cause IBS. Key words: Irritable bowel syndrome, gastrointestinal motility, visceral hypersensitivity, perception