Role of kinins in the vascular extravasation evoked by antigen and mediated by tachykinins in guinea pig trachea.

摘要: Tachykinins released from sensory nerves mediate, at least in part, the plasma extravasation induced by allergen challenge to airways of sensitized guinea pigs. We investigated role kinins this activation nerves. found that increase Evans blue dye evoked aerosol bradykinin (100 microM, 2 min) presence phosphoramidon (2.5 mg/kg, i.v.) was abolished completely selective B2 antagonist, HOE 140 (0.1 mumol/kg, i.v.), and inhibited (60%) NK1 tachykinin receptor CP-96,345 (2 i.v.). Plasma aerosolized substance P (10 microM/kg, CP-96,345, but not affected 140. The OVA (5%, pigs reduced (45%) when animals were perfused after 5 min 39% perfusion performed 10 min. In phosphoramidon, response 57% 72% CP-96,345. combination did further inhibition obtained with alone. results provide evidence contribute Ag-evoked is due kinin release. contribution cascade events may be exaggerated pathophysiologic conditions which neutral endopeptidase down-regulated.