Myofibroblasts in Head and Neck Surgery: An Experimental and Clinical Study

摘要: • Myofibroblasts in human granulation tissue have many of the structural and functional characteristics smooth-muscle cells appear to be responsible for wound contraction. They also been identified contracted scar nongranulation wounds. In this report, their role head neck healing will explored utilizing transmission electron microscopy immunoperoxidase techniques with antibodies intermediate filament vimentin muscle-restricted actins. piglets, high-tension, low-tension, granulating wounds were created studied serial biopsy specimens. Results showed few myofibroblasts either high- or low-tension multiple clinical studies, technique monoclonal antibody muscle-specific actins proved most useful identifying myofibroblasts. present hypertrophic scars. not widely mature keloids. (Arch Otolaryngol Head Neck Surg1988;114:982-986)