Perioperative assessment of platelet function by Thromboelastograph ® Platelet Mapping™ in cardiovascular patients undergoing non-cardiac surgery

摘要: Five percent of patients on dual antiplatelet therapy after coronary artery stent implantation will need non-cardiac surgery within the first year therapy, and many more later on. A function assay that evaluates platelet reactivity inhibition by drug is beneficial for such patients. Platelet Mapping (PM™) using TEG® analyzer was tested in surgical After IRB approval, 60 combined aspirin clopidogrel were consented enrolled. The maximal amplitude (MA) percentage (%) recorded analyzed. Fifty-seven (mean age 65.7 ± 10.9 years) had preoperative data only. Distribution ADP (43.6 ± 24.4 %) AA (52.8 ± 30.2 %) determined, as well MA (43.1 ± 15.9 mm) (37.2 ± 19.6 mm), showing an offset effect both medications starting from day 3. Patients with complete pre- postoperative stratified depending duration off (≤3 days, 3–7 days >7 days): n = 27, % preop (43.2 ± 21.6 %), postop (32.3 ± 18.3 %), p = 0.048. immediate post- inhibitions, a possible reduction Δ at 3 days, also assessed. Conclusion: According to findings, PM™ might be feasible approach objectively evaluate effects during perioperative period potentially guide management.