The inability of bromocriptine to inhibit prolactin secretion by transplantable rat pituitary tumors: observations on the mechanism and dynamics of the autofeedback regulation of prolactin secretion.
作者： STEVEN W. J. LAMBERTS , ROBERT M. MACLEOD
关键词: Bromocriptine 、 Internal medicine 、 Pituitary gland 、 Ergocryptine 、 Hormone 、 Pituitary neoplasm 、 Endocrinology 、 Prolactin 、 Hypothalamus 、 Ergotamine 、 Biology
摘要: The effect of several ergot alkaloids on the growth transplantable rat PRL- and GH-secreting tumors MtTW15 7315α was measured. In vivo administration ergotamine ergocryptine caused a significant decrease in tumor decreased serum PRL concentration. Tumor regression not blocked by concomitant haloperidol, dopamine antagonist. bromocriptine (0.8-40 mg/kg daily) did cause nor it suppress elevated levels. Since but are potent vasoconstrictor agents, is suggested that former derivatives capillary blood supply to thereby secretion. High concentrations known produce atrophy hosts' pituitary gland its synthesis release PRL. significantly secretion tumor, less tonic inhibitory signal pres...
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