Hyperprolactinemia Exerts a Negative Effect on the β-Endorphin Content of the Rat Neurointermediate Pituitary Lobe
作者： STEVEN W. J. LAMBERTS , PIET UITTERLINDEN , ELLEN G. BONS , JOKE M. ZUIDERWIJK , THEO VERLEUN
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摘要: Implantation of the PRL, ACTH, β-endorphin (β-EP), and β-lipotropin (β-LPH)-secreting transplantable rat pituitary tumor 7315a resulted in a suppression PRL ACTH content anterior gland also β-EP/β-LPH neurointermediate (NI) lobe. Treatment with bromocriptine further diminished lobe content, whereas haloperidol partially inhibited this tumor-mediated diminution. The administration these drugs did not influence suppressed NI tumorbearing rats became completely normal after treatment haloperidol, content. There was close correlation between all four groups taken together (including nontumorbearing controls, control rats, treated bromo...
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