A mu-opiate receptor in 7315c tumor tissue mediates inhibition of immunoreactive prolactin release and adenylate cyclase activity.
作者： E. A. FREY , J. W. KEBABIAN
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摘要: Cells of the 7315c tumor released immunoreactive PRL (IR-PRL). Cholera toxin enhanced this release. Morphine and other opiate agonists inhibited IR-PRL release from, both untreated cholera toxin-treated cells. The opiate-induced inhibition was concentration dependent naloxone sensitive. also adenylate cyclase activity tissue. Opiates enzyme in toxintreated tissue a concentration-dependent naloxonesensitive manner. FK 33824 more potent than [D-Ala2,D-Leu6] enkephalin inhibiting activity. In tissue, GTP required for Nonhydrolyzable analogs toxin-stimulated absence an opiate. These results suggest that possesses μ-opiate receptor; stimulation receptor inhibits ...
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