Anti-CD44 treatment abrogates tissue oedema and leukocyte infiltration in murine arthritis.

摘要: A ubiquitous cell adhesion receptor, CD44, preferentially binds hyaluronan, a poly-saccharide macromolecule that is present in most extracellular matrices. Hyaluronan molecules have large hydrodynamic volumes entrap substantial amounts of water and can therefore control tissue hydration (swelling). CD44 overexpressed by synovial cells leukocytes, hyaluronan overproduced the rheumatoid synovium other inflammatory sites. Nevertheless, role CD44–hyaluronan interaction during inflammation unclear. Our evidence shows receptor plays critical governing migration leukocytes into extravascular compartment murine arthritis. An anti-CD44 antibody induces rapid loss from both displays an inhibitory effect on cell–extracellular matrix interactions synovium. As result, administration such abrogates swelling leukocyte infiltration, two major components inflammation.