Role of methylglyoxal in Alzheimer's disease.

摘要: Alzheimer's disease is the most common and lethal neurodegenerative disorder. The major hallmarks of are extracellular aggregation amyloid β peptides and, presence intracellular neurofibrillary tangles formed by precipitation/aggregation hyperphosphorylated tau protein. etiology multifactorial a full understanding its pathogenesis remains elusive. Some years ago, it has been suggested that glycation may contribute to both extensive protein cross-linking oxidative stress in disease. Glycation an endogenous process leads production class compounds known as advanced end products (AGEs). Interestingly, increased levels AGEs have observed brains patients. Methylglyoxal, reactive intermediate cellular metabolism, potent precursor strictly correlated with increase Many studies showing methylglyoxal methylglyoxal-derived play key role etiopathogenesis