Variation in the type I interferon gene cluster on 9p21 influences susceptibility to asthma and atopy
作者： A Chan , D L Newman , A M Shon , D H Schneider , S Kuldanek
关键词: Biology 、 Genotype 、 Genetics 、 Allele 、 Short Tandem Repeat Polymorphism 、 Immunology 、 Atopy 、 Gene 、 Gene cluster 、 Haplotype 、 Exon
摘要: A genome-wide screen for asthma and atopy susceptibility alleles conducted in the Hutterites, a founder population of European descent, reported evidence linkage with short tandem repeat polymorphism (STRP) within type I interferon (IFN) gene cluster on chromosome 9p21. The goal this study was to identify variation IFN that influences atopic phenotypes. We screened approximately 25 kb sequence, including flanking sequence all 15 functional genes single coding exon 12, Hutterites representing different IFNA-STRP genotypes. identified 78 polymorphisms, genotyped 40 these (in 14 genes) large Hutterite pedigree. Modest associations (0.003
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