Highly Selective Room-Temperature Copper-Catalyzed C−N Coupling Reactions

摘要: Through the use of cyclic beta-diketones as supporting ligands, copper-catalyzed coupling aryl iodides with aliphatic amines occurs at room temperature in little 1 h. These high reaction rates allow for a wide range and heteroaryl temperature. This method is highly tolerant number reactive functional groups, including -Br aromatic -NH2 well phenolic -OH. The selectivity CuI-beta-diketone catalyst represents useful complement to palladium-based methods.