Noise Propagation in Gene Networks
作者： Juan M Pedraza , Alexander van Oudenaarden
关键词: Mathematics 、 Cellular noise 、 Isolated cell 、 Stochastic process 、 Signal fidelity 、 Gene Circuits 、 Gene regulatory network 、 Regulation of gene expression 、 Genetics 、 Biological system 、 Noise propagation 、 Multidisciplinary
摘要: Accurately predicting noise propagation in gene networks is crucial for understanding signal fidelity natural and designing noise-tolerant circuits. To quantify how propagates through networks, we measured expression correlations between genes single cells. We found that a was determined by its intrinsic fluctuations, transmitted from upstream genes, global affecting all genes. A model developed explains the complex behavior exhibited reveals dominant sources. The successfully predicts as network systematically perturbed. This approach provides step toward manipulating more networks.
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